What question did this study set out to answer?

Assess the accuracy of existing equations for lung diffusing capacity in Latin American groups residing at different altitudes.

March 18, 2026Open Access

Evaluation of the performance of the reference equations for single-breath diffusing capacity of the lung for carbon monoxide (DLCOsb) in Latin American populations at different altitudes: A multicentre study

Key Points

Assess the accuracy of existing equations for lung diffusing capacity in Latin American groups residing at different altitudes.
Multicentre study across Latin American populations
Comparison of DLCOsb values using various reference equations
Adjustment for altitude and hemoglobin (Hb) levels
Vázquez-García's equation performed best among the models
GLI model underestimated predicted DLCOsb values even after adjustments
Significant variation in performance was observed across different altitudes

Abstract

Although with wide limits of agreement for all models, Vázquez-García's equation shows the best performance in the interpretation of DLCOsb in Latin American populations residing at any altitude. Even with adjustments for altitude and Hb, the GLI model underestimates the predicted values of DLCOsb and could require an adjustment factor or inclusion of the altitude variable in the model's new version.

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Cite This Study

Aguirre-Franco et al. (Mon,) studied this question.

synapsesocial.com/papers/69ba43694e9516ffd37a4a5c https://doi.org/https://doi.org/10.1080/25310429.2026.2638013

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