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Assess the accuracy of existing equations for lung diffusing capacity in Latin American groups residing at different altitudes.

March 18, 2026PulmonologyOpen Access

Evaluation of the performance of the reference equations for single-breath diffusing capacity of the lung for carbon monoxide (DLCOsb) in Latin American populations at different altitudes: A multicentre study

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Multicentre study shows Vázquez-García's equation better interprets DLCOsb at varying altitudes, suggesting needed adjustments for accuracy.

Assess the accuracy of existing equations for lung diffusing capacity in Latin American groups residing at different altitudes.
Multicentre study across Latin American populations
Comparison of DLCOsb values using various reference equations
Adjustment for altitude and hemoglobin (Hb) levels
Vázquez-García's equation performed best among the models
GLI model underestimated predicted DLCOsb values even after adjustments
Significant variation in performance was observed across different altitudes

Aguirre-Franco et al. (2026) studied this question.

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Multicentre study shows Vázquez-García's equation better interprets DLCOsb at varying altitudes, suggesting needed adjustments for accuracy.