What question did this study set out to answer?

To establish normative reference equations for single-breath carbon monoxide diffusing capacity, alveolar volume, and their ratio in a representative healthy nonsmoking population.

April 1, 1987American Review of Respiratory Disease

The Single-Breath Carbon Monoxide Diffusing Capacity

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Authors

RKRonald J. KnudsonBoston University WKWalter T. KaltenbornUniversity of Arizona DKDwyn E. KnudsonHarvard University

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Implication

Cross-sectional study reports reference equations for single-breath carbon monoxide diffusing capacity in healthy nonsmokers, highlighting the effects of age, height, and female hematocrit.

Key Points

To establish normative reference equations for single-breath carbon monoxide diffusing capacity, alveolar volume, and their ratio in a representative healthy nonsmoking population.
Assessed a randomly selected representative community sample using standard protocols from the ATS-sponsored Epidemiology Standardization Project.
Derived reference equations from acceptable duplicate pulmonary function test results in N=228 healthy nonsmokers.
Generated reference equations for diffusing capacity (DL), alveolar volume (VA), and DL/VA that accounted for variation associated with growth, height, and age.
Identified a measurable physiological effect of hematocrit on DL and DL/VA in females, which was not observed in males due to a lower frequency of low hematocrit values.

Cite This Study

Knudson et al. (1987) studied this question.

synapsesocial.com/papers/6a75bf20f718b06d6813c6ee https://doi.org/10.1164/arrd.1987.135.4.805

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Implication

Cross-sectional study reports reference equations for single-breath carbon monoxide diffusing capacity in healthy nonsmokers, highlighting the effects of age, height, and female hematocrit.

The Single-Breath Carbon Monoxide Diffusing Capacity

Discussion

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Implication

Key Points

Cite This Study

The Single-Breath Carbon Monoxide Diffusing Capacity

Discussion

Member takes

Implication

Key Points

Cite This Study

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