What question did this study set out to answer?

To investigate protein interactions within mitochondria of live tumor-bearing mice using crosslinker nanocarriers.

March 25, 2026Open Access

Crosslinker Nanocarriers-based Intratumoral Delivery for Protein Complex Mapping in Mitochondria of Live Tumor-Bearing Mice

Key Points

To investigate protein interactions within mitochondria of live tumor-bearing mice using crosslinker nanocarriers.
Utilized crosslinking mass spectrometry for protein analysis.
Delivered protein complexes intratumorally via nanocarriers.
Performed in vivo studies with live tumor-bearing mice.
Expanded understanding of mitochondrial protein interactions in tumors.
Revealed specific protein complexes associated with tumor metabolism.
Demonstrated effective targeting of mitochondria using nanocarriers.

Abstract

Mitochondria, the powerhouses of the cell, are central to tumor initiation and growth, yet their protein interactions in living tumors remain poorly understood. Although crosslinking mass spectrometry (XL-MS) has revealed...

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Cite This Study

Chen et al. (Thu,) studied this question.

synapsesocial.com/papers/69c37b20b34aaaeb1a67d391 https://doi.org/https://doi.org/10.1039/d6sc00098c

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