Synthesis and Properties of 1,3-Disubstituted Ureas Based on a Naphthyl Propionic Acid Derivative Naproxen

Key Points

• The aim is to synthesize 1,3-disubstituted ureas and evaluate their inhibitory properties on specific enzymes.
• Synthesize 1,3-disubstituted ureas using 2-(1-isocyanatoethyl)-6-methoxynaphthalene.
• Use adamantyl-containing, cyclic, and aromatic amines in the synthesis process.
• Measure yields of synthesis ranging from 85% to 93%.
• The synthesized ureas demonstrated promising inhibition of human soluble epoxide hydrolase.
• Potential inhibition of cyclooxygenase-2 was also indicated.