This investigation synthesizes 1,3-disubstituted ureas to explore their inhibition of soluble epoxide hydrolase and cyclooxygenase-2.
A series of 1,3-disubstituted ureas was synthesized in 85–93% yield by the reaction of 2-(1-isocyanatoethyl)-6-methoxynaphthalene with adamantyl-containing, cyclic, and aromatic amines. The synthesized ureas are promising inhibitors of human soluble epoxide hydrolase (sEH) and potential inhibitors of cyclooxygenase (COX-2).
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Dyachenko et al. (2026) studied this question.
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