Synthesis and Properties of 1,3-Disubstituted Ureas and Its Isosteric Analogs Containing Polycyclic Fragments: XIX. Exo-Isomers of 1-(1,7,7-Trimethylbicyclo[2.2.1]heptan-2-yl)- 3-R Ureas and Thioureas

For a comprehensive assessment of the enantiomeric stereospecificity of human soluble epoxide hydrolase (hsEH), 1,3-disubstituted ureas and thioureas containing a bornyl fragment in their structure were synthesized according to the reaction exo-(R or S)-1,1,7-trimethylbicyclo[2.2.1]heptane-2-amine with aromatic isocyanates and isothiocyanates with yields up to 99%. Synthesized compounds are promising inhibitors of hsEH.