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November 25, 2025ChemistrySelectOpen Access

Synthesis, Structural Characterization, Biological and Computational Evaluation of Oxazolidin‐2‐one‐Based Carbonylsulfamates as Urease Inhibitors

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Authors

DBDounia BeldjezziaBadji Mokhtar-Annaba UniversityAAAϊcha AmiraHBHouria Bentoumi

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Implication

New oxazolidin‐2‐one derivatives show improved urease inhibition with IC50 of 70µM, highlighting potential for treating infections.

Key Points

  • This research aims to evaluate the potential of new oxazolidin‐2‐one derivatives as urease inhibitors.
  • Synthesized oxazolidin‐2‐one derivatives with chlorosulfonyl isocyanate and phenols.
  • Characterized structures using NMR, IR, mass spectroscopy, and X‐ray crystallography.
  • In vitro screening of derivatives for urease inhibition compared to thiourea.
  • In silico evaluations included molecular docking and dynamics simulations.
  • Compounds 5c and 5e showed IC50 values of 70 ± 0 µM, outperforming standard thiourea (130 ± 0 µM).
  • Strong correlations between experimental results and computational predictions were observed.

Cite This Study

Beldjezzia et al. (2025) studied this question.

synapsesocial.com/papers/692502b787af00ed34ac1f0dhttps://doi.org/10.1002/slct.202504979
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