Discovery of Novel 1,3,4-oxadiazole-based Inhibitors Against Urease and Diabetes: Design, Synthesis, SAR, Biological, and Molecular Docking Screening

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Novel compounds showed dual inhibition against urease and α-glucosidase, suggesting therapeutic potential.

Compounds demonstrated urease inhibition with IC50 values as low as 17.90 µM, outperforming standard thiourea.
Scaffolds exhibited strong α-glucosidase inhibition, with IC50 ranging from 3.19 to 12.24 µM across tested compounds.
Molecular docking confirmed strong binding affinities to target enzymes, correlating with their experimental inhibitory activity.
Compounds bearing electron-withdrawing groups enhanced enzyme inhibition, supporting their design for therapeutic applications.

Arshad et al. (2025) studied this question.

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