Substituted Ureas and Their Analogues Containing Framework Fragments. II. 1,1'-(4-(Adamantan-1-yl)-1,2-phenylene)bis(3-(R-phenylureas)) and Thioureas

The article presents a method for obtaining adamantlyl-containing 1,3-disubstituted diureas and dithioureas containing a 4-(adamantan-1-yl)-1,2-phenylene fragment. The target compounds were synthesized by the reaction of 4-(adamantan-1-yl)benzene-1,2-diamine with aromatic isocyanates and isothiocyanates with yields of 66–93%. It was found that, for the reaction to proceed to high conversion degrees in 12 h, no addition of a base (Et3N) to the reaction mass is required. The proposed approach allows simplifying the synthesis, isolation and purification of the reported compounds.