Carbonic Anhydrase Inhibitors: Ureido and Thioureido Derivatives of Aromatic Sulfonamides Possessing Increased Affinities for Isozyme I. A Novel Route To 2,5-Disubstituted-L,3,4-Thiadiazoles Via Thioureas, and Their Interaction with Isozymes I, II and IV
Population
Carbonic anhydrase (CA) isozymes I, II, and IV
Design
Preclinical
Authors
Discussion
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Member takes
Implication
These derivatives may guide selective CA I inhibitor development; leaves open any cardiovascular applications pending human studies.
Structured PICO
P
Population
Carbonic anhydrase (CA) isozymes I, II, and IV
I
Intervention
Ureido and thioureido derivatives of aromatic sulfonamides, and 2,5-bis(substituted-phenyl)-1,3,4-thiadiazole derivatives
O
Outcome
Inhibition of carbonic anhydrase isozymes I, II, and IVsurrogate
The newly synthesized ureido and thioureido derivatives of aromatic sulfonamides may serve as lead molecules for developing more selective CA I inhibitors.
Cite This Study
Scozzafava et al. (1998) studied this question.