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March 26, 2026

Gestational diabetes status modifies pre‐pregnancy BMI associations with large for gestational age: A prospective cohort study in central China

Key Points

To explore how gestational diabetes status affects the relationship between pre-pregnancy BMI and the risk of having a large for gestational age baby.
Conducted a prospective cohort study in central China.
Assessed pre-pregnancy BMI and gestational diabetes status.
Evaluated associations with large for gestational age outcomes.
Gestational diabetes significantly alters the relationship between pre-pregnancy BMI and LGA risk.
Identified a specific threshold of BMI that increases risk among women with gestational diabetes.
Findings suggest targeted interventions could help manage high-risk pregnancies.

Abstract

GDM status significantly modifies the relationship between pre-pregnancy BMI and LGA risk, identifying a threshold that substantially increases risk in women with GDM and revealing subgroup-specific vulnerabilities. These findings suggest that incorporating pre-pregnancy BMI and estimated risk of developing GDM into early risk stratification can help identify high-risk pregnancies, thereby guiding targeted antenatal monitoring and individualized interventions of varying stringency to prevent LGA.

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Cite This Study

Wu et al. (Tue,) studied this question.

synapsesocial.com/papers/69c4ccf7fdc3bde448918bcf https://doi.org/https://doi.org/10.1002/ijgo.70981

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