This prospective cohort study shows gestational diabetes modifies the impact of pre-pregnancy BMI on the risk of large for gestational age, suggesting personalized monitoring strategies.
GDM status significantly modifies the relationship between pre-pregnancy BMI and LGA risk, identifying a threshold that substantially increases risk in women with GDM and revealing subgroup-specific vulnerabilities. These findings suggest that incorporating pre-pregnancy BMI and estimated risk of developing GDM into early risk stratification can help identify high-risk pregnancies, thereby guiding targeted antenatal monitoring and individualized interventions of varying stringency to prevent LGA.
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Wu et al. (2026) studied this question.
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