Tobacco-specific Alkaloids (TSA) Formation in Aged E-cigarette Juices: Mechanistic Insights into Hydroxyl Radical–Initiated Nicotine Oxidation

Key Points

• The aim is to investigate how nicotine oxidizes in e-cigarette juices during indoor storage.
• Analyzed aged e-cigarette juice samples for chemical composition.
• Studied the mechanisms of nicotine oxidation involving hydroxyl radicals.
• Monitored changes in tobacco-specific alkaloid levels over time.
• Identified significant formation of tobacco-specific alkaloids during storage.
• Confirmed that hydroxyl radicals play a crucial role in nicotine oxidation.
• Observed chemical transformations that alter the e-juice profile over time.