Tobacco-specific Alkaloids (TSA) Formation in Aged E-cigarette Juices: Mechanistic Insights into Hydroxyl Radical–Initiated Nicotine Oxidation

Xinyang Guo; Bradley H. Isenor; Kimberly Wong; James Davis; Arthur W.K. Chan; Ran Zhao

doi:10.1039/d5em01030f

January 1, 2026Environmental Science Processes & ImpactsOpen Access

Tobacco-specific Alkaloids (TSA) Formation in Aged E-cigarette Juices: Mechanistic Insights into Hydroxyl Radical–Initiated Nicotine Oxidation

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Key Points

The aim is to investigate how nicotine oxidizes in e-cigarette juices during indoor storage.
Analyzed aged e-cigarette juice samples for chemical composition.
Studied the mechanisms of nicotine oxidation involving hydroxyl radicals.
Monitored changes in tobacco-specific alkaloid levels over time.
Identified significant formation of tobacco-specific alkaloids during storage.
Confirmed that hydroxyl radicals play a crucial role in nicotine oxidation.
Observed chemical transformations that alter the e-juice profile over time.

Implication

Laboratory study examines nicotine oxidation in e-cigarette juices, indicating storage impacts quality.

Abstract

Vaping e-cigarette juice (e-juice) is popular among young consumers. Although e-juice compositions are well characterized, chemical transformations during indoor storage are often overlooked. Particularly, the fundamentals of nicotine oxidation in...

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Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/69c4cd05fdc3bde448918d5a https://doi.org/10.1039/d5em01030f

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Tobacco-specific Alkaloids (TSA) Formation in Aged E-cigarette Juices: Mechanistic Insights into Hydroxyl Radical–Initiated Nicotine Oxidation

Key Points

Implication

Abstract

Discussion

Cite This Study

Tobacco-specific Alkaloids (TSA) Formation in Aged E-cigarette Juices: Mechanistic Insights into Hydroxyl Radical–Initiated Nicotine Oxidation

Key Points

Implication

Abstract

Discussion

Cite This Study

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