What question did this study set out to answer?

To compare the effectiveness and safety of intramuscular olanzapine and haloperidol for treating agitation in patients with and without substance use.

March 26, 2026

When Agitation Meets Intoxication: A Retrospective Comparison of Intramuscular Olanzapine and Haloperidol Among Patients With and Without Substance Use in a Psychiatric Emergency Service

Key Points

To compare the effectiveness and safety of intramuscular olanzapine and haloperidol for treating agitation in patients with and without substance use.
Retrospective analysis of patient records
Comparison of response to IM olanzapine and haloperidol
Assessment of safety concerns related to treatments
Patients with substance use showed similar or greater responses to both medications
No increase in safety concerns was observed in patients with substance use
Findings suggest implications for treating agitation in high-risk populations

Abstract

Patients with active substance use exhibited similar or greater responses to standard IM treatment for agitation without increased safety concerns. Findings support potential safety and efficacy of common pharmacologic approaches in this high-risk population, though a modest single-site cohort may limit generalizability. There is a need for prospective, multisite replication.

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Cite This Study

Lynch et al. (Mon,) studied this question.

synapsesocial.com/papers/69c4cd5afdc3bde448919972 https://doi.org/https://doi.org/10.1177/29767342261427167

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