Retrospective comparison reveals similar effectiveness of medications for agitation in patients with substance use, suggesting safety for treatment.
Patients with active substance use exhibited similar or greater responses to standard IM treatment for agitation without increased safety concerns. Findings support potential safety and efficacy of common pharmacologic approaches in this high-risk population, though a modest single-site cohort may limit generalizability. There is a need for prospective, multisite replication.
No takes yet. Share an insight, caveat, or question.
Lynch et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: