Wnt5a‐Induced Exosomes From Bone Marrow Mesenchymal Stem Cells Promote Spinal Cord Injury Repair by Modulating Immune Cell Phenotypes and Alleviating Neuroinflammation via the NF ‐ κB Pathway

Key Points

• This research aims to investigate how Wnt5a-induced exosomes affect spinal cord injury repair mechanisms.
• Examine the role of Wnt5a in bone marrow mesenchymal stem cell (BMSC) exosome production.
• Analyze the modulation of immune cell phenotypes by these exosomes.
• Assess the impact on neuroinflammation via NF-κB pathway inhibition.
• Wnt5a significantly enhances the neuroregenerative potential of BMSC-derived exosomes.
• Exosomes alter immune cell phenotypes favorably for repair processes.
• Inhibition of the NF-κB pathway correlates with reduced neuroinflammation.