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An optimized MP2RAGE protocol for spinal cord imaging in multiple sclerosis | Synapse

March 29, 2026Open Access

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An optimized MP2RAGE protocol for spinal cord imaging in multiple sclerosis

Key Points

To develop an optimized MP2RAGE MRI protocol for efficient spinal cord imaging in multiple sclerosis.
Used a 3T MRI scanner for spinal cord imaging.
Optimized MP2RAGE protocol designed for the entire cervical spinal cord.
Protocol aimed to achieve high tissue contrast-to-noise ratio (CNR).
Protocol covers the entire cervical spinal cord in about 5 minutes.
Demonstrated lesion-detection efficacy comparable to established methods.
Improved area quantification for clinical research applications.

Abstract

We present a 3T spinal cord-optimized MP2RAGE protocol capable of covering the entire cervical spinal cord in approximately 5 minutes. This protocol offers high tissue CNR-fundamental for area quantification-, as well as lesion-detection efficacy comparable to that of established methods. Therefore, such a single MRI protocol could be an efficient approach for conducting clinical research.

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Cite This Study

Papinutto et al. (Thu,) studied this question.

synapsesocial.com/papers/69c8c1d7de0f0f753b39bfea https://doi.org/https://doi.org/10.3174/ajnr.a9313