What question did this study set out to answer?

The research aims to clarify the role of enzymatic oxygen reduction in thermogenesis within mitochondria and its implications for energy dissipation in redox systems.

April 1, 2026Chemical Science0 citationsOpen Access

Enzymatic oxygen reduction dominates overpotential-driven thermogenesis in mitochondria

NNNuning Anugrah Putri Junji NamariKyushu University MYMo YanKyushu University JNJunji NakamuraKyushu University

Key Points

The research aims to clarify the role of enzymatic oxygen reduction in thermogenesis within mitochondria and its implications for energy dissipation in redox systems.
Analyzed chemical energy dissipation processes in mitochondria
Investigated the impacts of overpotential on thermogenesis
Conducted comparative studies with electrochemical systems
Enzymatic oxygen reduction significantly exceeds overpotential-driven thermogenesis
Thermogenesis was influenced by mitochondrial redox dynamics
Findings support a model for energy dissipation in non-equilibrium redox conditions

Abstract

Understanding how chemical energy dissipates as heat in non-equilibrium redox systems is a fundamental problem in physical chemistry. While this phenomenon is well described in electrochemical systems such as fuel...

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