Aloe-emodin microemulsion gel for diabetic wounds: optimizing surfactant–polymer synergy for effective wound management

Key Points

• The aim is to evaluate the effectiveness of aloe-emodin microemulsion gel in managing diabetic wounds.
• Developed a microemulsion gel using surfactant and polymer combinations.
• Tested the solubility and bioavailability of aloe-emodin in the gel.
• Assessed the penetration and release characteristics of the gel on wound models.
• The microemulsion gel significantly improved the solubility of aloe-emodin.
• Enhanced the penetration of the gel into diabetic wounds was observed.
• Controlled release of aloe-emodin promoted effective healing compared to traditional treatments.