Influence of tumor-draining lymph nodes on immunotherapy: lymphadenectomy may have its limits

Key Points

• The research investigates if reducing the removal of tumor-draining lymph nodes can improve outcomes for patients receiving immunotherapy.
• Explored effects of fewer lymph nodes removed during surgical resection
• Assessed adaptive immune responses in lymph nodes
• Analyzed clinical outcomes of neoadjuvant immunotherapy
• Removing fewer tumor-draining lymph nodes may retain beneficial immune responses
• Neoadjuvant immunotherapy shows notable success when less lymphadenectomy is performed
• Potential for improved outcomes in certain patient populations