This analysis examines lymphadenectomy effects on immunotherapy outcomes in populations, suggesting potential implications for surgical practices.
In this CCR Translations, it is explored whether removing fewer than usual tumor-draining lymph nodes at surgical resection might offer better outcomes in patients subsequently receiving immunotherapy. These lymph nodes likely host coordinated adaptive immune responses, and may be a key reason why neoadjuvant immunotherapy is exhibiting remarkable clinical success.
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Robert H. Vonderheide (2026) studied this question.
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