Does ramipril retard the development of aortic valve stenosis in a rabbit model?
In a rabbit model, ramipril retards the development of aortic valve stenosis and limits endothelial dysfunction, providing a rationale for future human studies.
Ramipril retards the development of AVS, reduces valvular thioredoxin-interacting protein accumulation and limits endothelial dysfunction in this animal model. These findings provide important insights into the mechanisms of AVS development and an impetus for future human studies of AVS retardation using an angiotensin-converting enzyme inhibitor.
Ngo et al. (Wed,) studied this question.
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