Is the Angiotensin-Converting Enzyme (ACE) locus associated with hypertension and blood pressure in men and women?
The ACE locus shows sex-specific association and genetic linkage with hypertension and diastolic blood pressure in men.
In our large, population-based sample, there is evidence for association and genetic linkage of the ACE locus with hypertension and with diastolic blood pressure in men but not women. Our data support the hypothesis that ACE, or a nearby gene, is a sex-specific candidate gene for hypertension. Confirmatory studies in other large population-based samples are warranted.
O’Donnell et al. (Tue,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: