Key result
ACE locus links to hypertension and higher diastolic blood pressure in men, but not women.
Why the study?
The role of the ACE locus in hypertension and blood pressure regulation may differ by sex, requiring investigation in a large population-based sample.
Is the Angiotensin-Converting Enzyme (ACE) locus associated with hypertension and blood pressure in men and women?
Is the Angiotensin-Converting Enzyme (ACE) locus associated with hypertension and blood pressure in men and women?
The ACE locus shows sex-specific association and genetic linkage with hypertension and diastolic blood pressure in men.
Sex-specific ACE associations with hypertension warrant no practice change; leaves open replication in prospective cohorts.
In our large, population-based sample, there is evidence for association and genetic linkage of the ACE locus with hypertension and with diastolic blood pressure in men but not women. Our data support the hypothesis that ACE, or a nearby gene, is a sex-specific candidate gene for hypertension. Confirmatory studies in other large population-based samples are warranted.
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O’Donnell et al. (1998) studied this question. The angiotensin-converting enzyme (ACE) locus is associated and genetically linked with hypertension and diastolic blood pressure in men, but not in women.
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