Why the study?
Is the ACE insertion/deletion (I/D) polymorphism associated with essential hypertension in Japanese men and women?
Population
1,243 Japanese subjects, including 701 men and 542 women
Comparison
ACE insertion/deletion polymorphism vs ACE insertion/deletion polymorphism
Design
Case-control
Authors
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Does not support ACE I/D genotyping for hypertension risk; leaves open ethnic or interaction effects in other groups.
Is the ACE insertion/deletion (I/D) polymorphism associated with essential hypertension in Japanese men and women?
The ACE I/D polymorphism does not have a sex-specific association with essential hypertension in the Japanese population.
Sugiyama et al. (1999) studied this question.
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