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January 1, 1995American Journal of Hypertension

Angiotensin I converting enzyme (ACE) gene polymorphism and essential hypertension in JapanEthnic difference of ACE genotype

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Why the study?

Is the ACE gene polymorphism associated with essential hypertension in a Japanese population?

Population

182 Japanese subjects, comprising 87 hypertensive patients with a family history of essential hypertension…

Comparison

Presence of ACE gene polymorphism vs Normotensive subjects and populations from…

Design

Case-control

Authors

TITomoaki IshigamiGeneral CardiologyTITakashi IwamotoTokyo Medical UniversityKTKohji TamuraChoshu Industry (Japan)

Discussion

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Implication

ACE polymorphism was not associated with hypertension in Japanese adults; leaves open ancestry-specific genetic contributions to blood pressure.

Key Points

  • To investigate the relationship between ACE gene polymorphism and essential hypertension in a Japanese population.
  • Examined 87 hypertensive and 95 normotensive subjects
  • Used polymerase chain reaction to determine ACE gene polymorphism
  • Compared genotype and allele frequency in Japan with other countries.
  • Hypertensive group had genotype frequencies: II (0.51), ID (0.30), DD (0.19).
  • Normotensive group had: II (0.37), ID (0.45), DD (0.18).
  • No significant differences in derived allele frequencies between hypertensive and normotensive groups.

Structured PICO

Is the ACE gene polymorphism associated with essential hypertension in a Japanese population?

P
Population
182 Japanese subjects, comprising 87 hypertensive patients with a family history of essential hypertension and 95 normotensive patients without a parental history of hypertension.
I
Intervention
Presence of ACE gene polymorphism (II, ID, DD genotypes)
C
Comparator
Normotensive subjects (for hypertension risk) and populations from Europe and Australia (for allele frequency comparison)
O
Outcome
Association between ACE gene polymorphism and essential hypertensionsurrogate

The ACE gene polymorphism is not associated with essential hypertension in the Japanese population, although its allele frequency differs significantly from European and Australian populations.

Cite This Study

Ishigami et al. (1995) studied this question.

synapsesocial.com/papers/6a7047d4e71d69abee088161https://doi.org/10.1016/0895-7061(94)00184-d

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polymorphism of the angiotensin I converting enzyme gene is apparently not related to high blood pressure: Dutch Hypertension and Offspring Study1993 · 188 citations
  2. 2The angiotensin I converting enzyme gene and predisposition to high blood pressure.1993 · 233 citations
  3. 3Population genetics of the angiotensin‐converting enzyme in Chinese.1994 · 90 citations
  4. 4PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)1992 · 1,250 citations
  5. 5An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.1990 · 3,816 citations