May 1, 1996Circulation
Ischemic Stroke and the Gene for Angiotensin-Converting Enzyme in Japanese Hypertensives
Why the study?
Is the ACE I/D polymorphism associated with ischemic stroke in Japanese hypertensive patients?
Population
332 Japanese subjects (228 hypertensive and 104 normotensive)
Comparison
ACE insertion/deletion polymorphism vs Hypertensives without lacunae and normotensive…
Design
Case-control
Authors
Discussion
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Implication
Hypothesis-generating for ACE I/D in Japanese hypertensive stroke risk; prospective validation required before clinical consideration.
Structured PICO
Is the ACE I/D polymorphism associated with ischemic stroke in Japanese hypertensive patients?
P
Population
332 Japanese subjects (228 hypertensive and 104 normotensive)
I
Intervention
ACE insertion/deletion (I/D) polymorphism (ACE*D allele)
C
Comparator
Hypertensives without lacunae and normotensive controls
O
Outcome
Silent or clinically overt ischemic strokehard clinical
The ACE*D allele is positively associated with ischemic stroke in Japanese hypertensive patients, suggesting it may be an independent risk factor for cerebrovascular disease in this population.
Cite This Study
Kario et al. (1996) studied this question.