Key result
ACE-DD genotype linked to ~271% greater ischemic stroke risk in hypertensive patients versus healthy controls.
Why the study?
Previous studies on the involvement of the ACE gene I/D polymorphism in ischemic stroke yielded contradictory and conflicting data.
Does the ACE gene I/D polymorphism increase the risk of ischemic stroke in patients with hypertension?
Case-Control (n=72)
No
Does the ACE gene I/D polymorphism increase the risk of ischemic stroke in patients with hypertension?
The ACE gene I/D polymorphism (D allele) is significantly associated with an increased risk of ischemic stroke in Ethiopian patients with hypertension.
Should not yet guide ACE genotyping for stroke prevention in hypertension; supports prospective validation in diverse cohorts.
Background: Ischemic stroke is a complicated, multifaceted condition brought on by a confluence of vascular, environmental, and genetic variables. The burden of ischemic stroke is currently rising in terms of death, morbidity, and disability worldwide. Genetic variables also play significant roles in the pathophysiology of hypertension and ischemic stroke in addition to the greatest effects of demographic, clinical, and behavioral risk factors. The key functional variation of the ACE gene that has drawn the most interest is the ACE I/D variant. Even though the ACE gene I/D polymorphism has been widely studied, the findings of investigations on the involvement of this polymorphism in ischemic stroke were contradictory and provide conflicting data. The goal of this study was to look into the effect of the ACE gene I/D polymorphism on the risk of ischemic stroke in patients with hypertension. Methods: A hospital-based case-control study was carried out in 36 cases of patients with hypertensive IS and 36 age- and sex-matched healthy controls. Clinical and biochemical parameters were measured to assess the associated risk factors. The DNA was isolated from blood samples, and the ACE I/D genotypes were identified using polymerase chain reaction and analyzed by agarose gel electrophoresis. Conclusion: There is a significant correlation between the ACE gene I/D polymorphism and the development of ischemic stroke in patients with a history of hypertension in the Ethiopian population.
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Melake et al. (2023) conducted a case-control in Ischemic stroke in hypertension (n=72). ACE gene I/D polymorphism (ACE-DD genotype) vs. Healthy normotensive controls was evaluated on Association of ACE-DD genotype with ischemic stroke (OR 3.71, 95% CI 1.02-13.5, p=0.046). The ACE-DD genotype was significantly associated with an increased risk of ischemic stroke complications in hypertensive patients compared to healthy controls (OR 3.71).
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