Why the study?
Does the ACE (I/D) gene polymorphism increase the risk of ischemic stroke in Caucasian individuals?
Population
10,609 Caucasian individuals (5,528 ischemic stroke cases and 5,081 controls) from 22 case-control studies
Comparison
Angiotensin converting enzyme insertion/deletion… vs ACE gene polymorphism
Design
Meta-analysis
Authors
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ACE I/D polymorphism may raise ischemic stroke risk in Caucasians; confirms association from prior conflicting studies.
Does the ACE (I/D) gene polymorphism increase the risk of ischemic stroke in Caucasian individuals?
The ACE (I/D) gene polymorphism, specifically the DD genotype, is associated with an increased risk of ischemic stroke in Caucasian individuals, particularly for small vessel disease.
Yuan et al. (2015) studied this question.
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