Key result
The ACE gene D allele, acting recessively, is a modest but independent risk factor for ischaemic stroke onset (OR 1.31; 95% CI 1.06-1.62; p=0.01).
Why the study?
Does the ACE gene DD genotype increase the risk of ischaemic stroke in white subjects?
Population
1,918 white subjects (1,196 ischaemic stroke cases and 722 controls) from 7 case-control studies
Comparison
ACE gene DD genotype (D allele) vs Non-DD genotype (I allele)
Design
Meta-analysis
Authors
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Supports modest genetic risk stratification in white ischaemic stroke patients; extends candidate-gene meta-analyses but requires prospective validation before clinical use.
Meta-Analysis (n=1,918)
Does the ACE gene DD genotype increase the risk of ischaemic stroke in white subjects?
Odds Ratio: 1.31 (95% CI 1.06–1.62)
p-value: p=0.01
The ACE gene D allele, acting recessively, is a modest but independent risk factor for ischaemic stroke in white subjects.
Pankaj Sharma (1998) conducted a meta-analysis in Ischaemic stroke (n=1,918). ACE gene D allele (recessive model) vs. Other ACE genotypes was evaluated on Ischaemic stroke (OR 1.31, 95% CI 1.06-1.62, p=0.01). The ACE gene D allele, acting recessively, is a modest but independent risk factor for ischaemic stroke onset (OR 1.31; 95% CI 1.06-1.62; p=0.01).
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