Why the study?
Is the ACE I/D gene polymorphism (DD genotype) associated with an increased risk of coronary artery disease and myocardial infarction in male patients undergoing coronary angiography?
Population
301 male patients at a university medical center.
Comparison
ACE I/D gene polymorphism (DD genotype) vs ACE I/D gene polymorphism (DI and II genotypes)
Design
Cross-sectional
Authors
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No association in this angiographic cohort does not alter CAD risk assessment; leaves open ACE I/D relevance in broader or prospective settings.
Is the ACE I/D gene polymorphism (DD genotype) associated with an increased risk of coronary artery disease and myocardial infarction in male patients undergoing coronary angiography?
The ACE I/D gene polymorphism is not associated with an increased risk for coronary artery disease or myocardial infarction in angiographically defined male patients, despite its effect on plasma ACE activity.
Bernhard R. Winkelmann (1996) studied this question.
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