Key result
The ACE DD genotype, which had approximately twofold higher ACE activity than the II genotype, was associated with coronary artery disease and myocardial infarction only in low-risk patients.
Why the study?
Is the ACE gene I/D polymorphism or ACE catalytic activity associated with coronary artery disease and myocardial infarction?
Population
920 individuals who underwent coronary angiography for diagnostic purposes
Comparison
Angiotensin I-converting enzyme gene… vs II genotype and lower ACE catalytic activity
Design
Cross-sectional
Authors
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Hypothesis-generating for CAD risk stratification in low-risk patients; leaves open whether ACE genotyping adds incremental value.
Observational (n=920)
Is the ACE gene I/D polymorphism or ACE catalytic activity associated with coronary artery disease and myocardial infarction?
The ACE gene DD polymorphism, but not ACE catalytic activity, is associated with CAD and MI specifically in individuals lacking classic cardiovascular risk factors.
Gardemann et al. (1995) conducted an observational in Coronary artery disease and myocardial infarction (n=920). ACE I/D gene polymorphism and ACE activity was evaluated on Coronary artery disease and myocardial infarction. The ACE DD genotype, which had approximately twofold higher ACE activity than the II genotype, was associated with coronary artery disease and myocardial infarction only in low-risk patients.
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