Why the study?
Is the ACE I/D polymorphism associated with an increased risk of myocardial infarction?
Is the ACE I/D polymorphism associated with an increased risk of myocardial infarction?
The ACE I/D polymorphism (specifically the D allele) is an independent genetic risk factor for myocardial infarction, particularly in otherwise low-risk individuals.
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Supports ACE I/D genotyping to refine MI risk in low-risk patients; hypothesis-generating and requires prospective validation.
François Cambien (1994) studied this question.
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