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August 1, 1994CirculationOpen Access

Plasma ACE level was higher in MI patients than in control subjects in the younger age group (< 55 years) (P < .005 after adjustment on ACE I/D and other risk factors).

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Why the study?

Are plasma ACE levels and ACE gene polymorphism associated with an increased risk of myocardial infarction?

Population

Male patients with myocardial infarction and control subjects (n=1086 subsample of the ECTIM study)

Comparison

Plasma ACE levels and ACE gene polymorphism vs Control subjects without myocardial infarction

Design

Case-control

Authors

FCFrançois CambienOCO. CosterousseLTLaurence Tiret

Discussion

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Overview

Plasma ACE levels may mark elevated MI risk in adults <55 years; hypothesis-generating and requires prospective validation.

Structured PICO

Are plasma ACE levels and ACE gene polymorphism associated with an increased risk of myocardial infarction?

P
Population
Male patients with myocardial infarction and control subjects (n=1086 subsample of the ECTIM study)
I
Intervention
Plasma ACE levels and ACE gene polymorphism
C
Comparator
Control subjects without myocardial infarction
O
Outcome
Myocardial infarction (association with plasma ACE levels and ACE gene polymorphism)hard clinical

Plasma ACE level may be an independent risk factor for myocardial infarction, particularly in younger patients, independent of the ACE I/D polymorphism.

Cite This Study

Cambien et al. (1994) studied this question.

synapsesocial.com/papers/6a11c7d5a54a38d693fd35fehttps://doi.org/10.1161/01.cir.90.2.669
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