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September 1, 1999European Heart JournalOpen Access

Angiotensin I-converting enzyme gene polymorphism, coronary artery disease and myocardial infarction. An angiographically controlled study

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Why the study?

Does the ACE gene insertion/deletion polymorphism associate with the presence and extent of coronary artery disease or myocardial infarction in patients undergoing coronary angiography?

Population

1,310 Caucasian patients (969 men, 341 women) undergoing coronary angiography

Comparison

Angiotensin I-converting enzyme gene… vs Other ACE genotypes

Design

Cross-sectional

Authors

MPM. PfohlJohannes Gutenberg University MainzMKMatthias KochFederal Institute For Materials Research and TestingSPS. PrescodTH Bingen University of Applied Sciences

Discussion

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Implication

Supports no role for ACE DD genotyping in CAD risk assessment; leaves open validation in prospective cohorts.

Structured PICO

Does the ACE gene insertion/deletion polymorphism associate with the presence and extent of coronary artery disease or myocardial infarction in patients undergoing coronary angiography?

P
Population
1,310 Caucasian patients (969 men, 341 women) undergoing coronary angiography
I
Intervention
Angiotensin I-converting enzyme (ACE) gene insertion/deletion polymorphism (specifically the DD genotype)
C
Comparator
Other ACE genotypes
O
Outcome
Presence and extent of coronary artery disease (defined by >/=50% lumen narrowing) and myocardial infarctionhard clinical

The ACE insertion/deletion gene polymorphism is not associated with the prevalence or extent of coronary artery disease or myocardial infarction, indicating genotyping is not useful for individual risk assessment.

Cite This Study

Pfohl et al. (1999) studied this question.

synapsesocial.com/papers/6a86f67ca810ea404bcf9982https://doi.org/10.1053/euhj.1999.1543

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ACE Gene Polymorphism: Ischemic Heart Disease and Longevity in 10 150 Individuals1997 · 166 citations
  2. 2Genotype Distribution of Angiotensin-Converting Enzyme Polymorphism in Australian Healthy and Coronary Populations and Relevance to Myocardial Infarction and Coronary Artery Disease1996 · 45 citations
  3. 3Angiotensin converting enzyme gene deletion allele is independently and strongly associated with coronary atherosclerosis and myocardial infarction.1995 · 90 citations
  4. 4Association of ACE Gene Polymorphisms with Coronary Artery Disease in a Northern Area of Japan.1995 · 12 citations
  5. 5A DNA Variant at the Angiotensin-Converting Enzyme Gene Locus Associates With Coronary Artery Disease in the Caerphilly Heart Study1995 · 177 citations