August 15, 1996Circulation
A Meta-analysis of the Association of the Deletion Allele of the Angiotensin-Converting Enzyme Gene With Myocardial Infarction
Key result
The ACE DD genotype was associated with an increased risk of myocardial infarction compared to ID/II genotypes (OR 1.26; 95% CI 1.15-1.39; P<0.0001).
Why the study?
Does the ACE gene DD genotype increase the risk of myocardial infarction compared to ID/II genotypes?
Population
15 studies containing 3394 MI cases and 5479 control subjects
Comparison
ACE gene DD genotype vs ACE gene ID/II genotypes
Design
Meta-analysis
Authors
Discussion
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Member takes
Implication
ACE DD may modestly inform MI risk assessment; leaves open whether genotyping should guide therapy or prevention.
Study Design
Type
Meta-Analysis (n=8,873)
Multicenter
Yes
Structured PICO
Does the ACE gene DD genotype increase the risk of myocardial infarction compared to ID/II genotypes?
P
Population
Meta-analysis of 15 studies comprising 8,873 individuals (3,394 MI cases and 5,479 controls) evaluating the association of the ACE I/D genotype with myocardial infarction.
E
Exposure
ACE gene DD genotype
C
Comparator
ACE gene ID/II genotypes
O
Outcome
Myocardial infarctionhard clinical
Main Result
Odds Ratio: 1.26 (95% CI 1.15–1.39)
p-value: p=<.0001
This meta-analysis demonstrates a significant association between the ACE gene DD genotype and an increased risk of myocardial infarction.
Cite This Study
Samani et al. (1996) conducted a meta-analysis in Myocardial infarction (n=8,873). ACE DD genotype vs. ID/II genotypes was evaluated on Myocardial infarction (OR 1.26, 95% CI 1.15-1.39, p=<.0001). The ACE DD genotype was associated with an increased risk of myocardial infarction compared to ID/II genotypes (OR 1.26; 95% CI 1.15-1.39; P<0.0001).