What question did this study set out to answer?

To assess evidence supporting the hypothesis that the deletion (D) allele of the angiotensin-converting enzyme (ACE) gene is associated with increased mortality and cardiovascular complications.

January 1, 1996Clinical and Experimental Pharmacology and Physiology

Hypothesis: An Angiotensin Converting Enzyme/Genotype, Present in One in Three Caucasians, Is Associated With an Increased Mortality Rate

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Why the study?

Is the ACE DD genotype associated with an increased risk of mortality and cardiovascular events in Caucasians?

Population

Caucasians, particularly those with cardiovascular risk factors

Comparison

ACE gene deletion (D) allele / DD genotype vs ACE gene insertion (I) allele / II genotype

Design

Review

Authors

BMBrian J. MorrisNYU Langone Health

Discussion

Member takes

Implication

May flag higher-risk elderly hypertensives for closer monitoring; hypothesis-generating for genotype-guided strategies pending prospective trials.

Key Points

To assess evidence supporting the hypothesis that the deletion (D) allele of the angiotensin-converting enzyme (ACE) gene is associated with increased mortality and cardiovascular complications.
Reviewed published evidence on ACE insertion/deletion (I/D) polymorphism frequencies across varying age cohorts presenting with established cardiovascular risk factors.
Evaluated associations between the ACE DD genotype and secondary complications, including post-angioplasty restenosis, heart failure, ventricular hypertrophy, and diabetic nephropathy.
Homozygosity for the deletion allele (DD genotype) was associated with an increased risk of premature mortality in high-risk groups, including an odds ratio of 6.6 for DD versus II in hypertensive patients aged ≥60 years.
The DD genotype showed heightened prevalence in patients experiencing restenosis following balloon angioplasty, heart failure, ventricular hypertrophy, and diabetic nephropathy.

Structured PICO

Is the ACE DD genotype associated with an increased risk of mortality and cardiovascular events in Caucasians?

Population

Caucasians, particularly those with cardiovascular risk factors (hypertension, myocardial infarction, heart failure, ventricular hypertrophy, diabetic nephropathy)

Intervention

ACE gene deletion (D) allele / DD genotype

Comparator

ACE gene insertion (I) allele / II genotype

Outcome

Mortality rate and fatal cardiovascular eventshard clinical

The ACE DD genotype may serve as a common genetic risk factor for fatal cardiovascular events and increased mortality in high-risk patients.

Cite This Study

Brian J. Morris (1996) studied this question.

synapsesocial.com/papers/6a8cfc91cfe29b63049910b2 https://doi.org/10.1111/j.1440-1681.1996.tb03054.x

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Implication

May flag higher-risk elderly hypertensives for closer monitoring; hypothesis-generating for genotype-guided strategies pending prospective trials.

Hypothesis: An Angiotensin Converting Enzyme/Genotype, Present in One in Three Caucasians, Is Associated With an Increased Mortality Rate

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Hypothesis: An Angiotensin Converting Enzyme/Genotype, Present in One in Three Caucasians, Is Associated With an Increased Mortality Rate

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider