December 1, 1997Journal of Hypertension
The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk
Why the study?
Does possession of the D allele of the ACE gene increase the risk of cardiovascular-renal disorders compared to the II genotype?
Population
49,959 subjects from 145 case-control reports
Comparison
Possession of the D allele of the angiotensin… vs II genotype reference group
Design
Meta-analysis
Authors
Discussion
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Member takes
Implication
Alerts clinicians to heightened risk in DD carriers; extends meta-analytic evidence on ACE I/D variant while cautioning on publication bias.
Structured PICO
Does possession of the D allele of the ACE gene increase the risk of cardiovascular-renal disorders compared to the II genotype?
P
Population
49,959 subjects from 145 case-control reports
I
Intervention
Possession of the D allele (DD homozygotes or DI heterozygotes) of the angiotensin converting enzyme (ACE) gene
C
Comparator
II genotype reference group
O
Outcome
Risk of cardiovascular-renal disorders (coronary heart disease, myocardial infarction, stroke, diabetic nephropathy, hypertension, left ventricular hypertrophy, cardiomyopathy, diabetic retinopathy)hard clinical
The D allele of the ACE gene is a marker for increased risk of atherosclerotic cardiovascular complications and diabetic nephropathy, though publication bias may inflate these associations.
Limitations
- Publication bias observed for CHD, myocardial infarction and microvascular nephropathy
- Associations do not necessarily imply a causal relationship
Cite This Study
Staessen et al. (1997) studied this question.