Why the study?
Does the ACE DD genotype increase the risk of cardiovascular disease and hypertension?
Population
Populations studied for the association between ACE Insertion/Deletion polymorphism and cardiovascular…
Comparison
ACE DD genotype / D allele vs Non-DD genotypes
Design
Review
Authors
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ACE polymorphism testing lacks utility for hypertension or CVD risk assessment; leaves open ancestry-specific MI associations in select DD subgroups.
Does the ACE DD genotype increase the risk of cardiovascular disease and hypertension?
The clinical implications of the ACE I/D polymorphism in cardiovascular disease remain largely inconclusive due to conflicting data, though the DD genotype may increase myocardial infarction risk in specific subpopulations.
Wuyts et al. (1997) studied this question.
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