Key result
Carriers of the ACE D allele had a significantly increased risk of hypertrophic cardiomyopathy compared to the II genotype (OR 1.69), whereas no significant association was found for dilated cardiomyopathy.
Why the study?
Does the ACE I/D polymorphism increase the risk of dilated or hypertrophic cardiomyopathy?
Meta-Analysis (n=4,246)
Does the ACE I/D polymorphism increase the risk of dilated or hypertrophic cardiomyopathy?
Odds Ratio: 1.69 (95% CI 1.04–2.74)
p-value: p=0.03
The ACE I/D polymorphism (D allele) is associated with an increased susceptibility to hypertrophic cardiomyopathy, but not dilated cardiomyopathy.
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May inform HCM family screening; supports ACE D allele as susceptibility factor while leaving dilated cardiomyopathy links open.
Yang et al. (2013) conducted a meta-analysis in Dilated Cardiomyopathy (DCM) and Hypertrophic Cardiomyopathy (HCM) (n=4,246). ACE I/D polymorphism (D allele carriers) vs. ACE II genotype was evaluated on Risk of Hypertrophic Cardiomyopathy (HCM) (OR 1.69, 95% CI 1.04-2.74, p=0.03). Carriers of the ACE D allele had a significantly increased risk of hypertrophic cardiomyopathy compared to the II genotype (OR 1.69), whereas no significant association was found for dilated cardiomyopathy.
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