Why the study?
Are ACE and angiotensinogen gene polymorphisms associated with the development or progression of nonfamilial hypertrophic or dilated cardiomyopathy?
Population
281 individuals from a Japanese population, comprising 71 patients with nonfamilial hypertrophic…
Comparison
Presence of ACE insertion/deletion polymorphism… vs Healthy control subjects and comparison between…
Design
Case-control
Authors
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No association of ACE or angiotensinogen variants with nonfamilial HCM/DCM; leaves open whether other polymorphisms influence disease in Japanese patients.
Are ACE and angiotensinogen gene polymorphisms associated with the development or progression of nonfamilial hypertrophic or dilated cardiomyopathy?
ACE I/D and angiotensinogen M235T and T174M polymorphisms are not associated with the genesis or progression of nonfamilial HCM or DCM in the Japanese population.
Yoshiji Yamada (1997) studied this question.
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