Why the study?
Is the ACE gene DD genotype associated with an increased risk of myocardial infarction in middle-aged Japanese men?
Is the ACE gene DD genotype associated with an increased risk of myocardial infarction in middle-aged Japanese men?
The ACE gene DD genotype is a significant risk factor for myocardial infarction in middle-aged Japanese men, independent of traditional risk factors like hypercholesterolemia and obesity.
DD genotype associated with MI in Japanese men; hypothesis-generating and requires prospective validation before any clinical use.
An association study of the insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene with myocardial infarction (MI) was performed in middle-aged Japanese men. The DD genotype was significantly more frequent in 101 MI subjects (0.42) than in 102 matched control subjects (0.16) compared with the two other genotypes (IDandII) (p<0.00005). A significant association was observed not only in the low-risk group but also in the high-risk group who were defined according to plasma total cholesterol ≥ 220mg/dl and body mass index ≥ 26kg/m2. These results indicate that ACE/DD genotype is a potent and important risk factor for MI in Japanese. (Hypertens Res 1994; 17: 55-57)
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Zhao et al. (1994) studied this question.
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