Key result
The frequency of the ACE DD genotype was significantly lower among male survivors of myocardial infarction compared to controls (22.7% vs 34.9%, p=0.011), with no significant difference in women.
Why the study?
Is the ACE I/D polymorphism DD genotype associated with an increased risk of myocardial infarction?
Population
234 survivors of myocardial infarction and 366 controls
Comparison
Presence of the DD genotype in the… vs Controls without myocardial infarction
Design
Case-control
Authors
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ACE DD genotype does not appear to increase MI risk in men; hypothesis-generating and leaves the polymorphism's role open.
Case-Control (n=600)
Is the ACE I/D polymorphism DD genotype associated with an increased risk of myocardial infarction?
Absolute Event Rate: 22.7% vs 34.9%
p-value: p=0.011
The ACE DD genotype was found to be less frequent in male survivors of premature myocardial infarction compared to controls, contrasting with previous reports.
Bøhn et al. (1993) conducted a case-control in Myocardial infarction (n=600). Insertion/deletion (I/D) polymorphism at the ACE locus (DD genotype) vs. Controls was evaluated on Frequency of the DD genotype in males (p=0.011). The frequency of the ACE DD genotype was significantly lower among male survivors of myocardial infarction compared to controls (22.7% vs 34.9%, p=0.011), with no significant difference in women.
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