Key result
The DD genotype of the ACE gene was associated with a significantly higher frequency of premature parental myocardial infarction compared to the II genotype (14% vs 6.1%; OR 3.1, p=0.009).
Why the study?
Is the ACE gene I/D polymorphism associated with a parental history of premature myocardial infarction?
Population
595 individuals, comprising 181 male and 48 female myocardial infarction survivors, and 172 male and 194…
Comparison
ACE gene insertion/deletion polymorphism vs II genotype
Design
Case-control
Authors
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ACE DD genotype may mark familial premature MI risk; hypothesis-generating and should not yet change practice.
Case-Control (n=595)
Is the ACE gene I/D polymorphism associated with a parental history of premature myocardial infarction?
Odds Ratio: 3.1
Absolute Event Rate: 14% vs 6.1%
p-value: p=0.009
The ACE gene DD genotype is significantly associated with a parental history of premature myocardial infarction, suggesting it may be an important genetic marker for MI risk.
Bøhn et al. (1993) conducted a case-control in Myocardial infarction (n=595). DD genotype of the ACE gene vs. II genotype was evaluated on Premature parental myocardial infarction (OR 3.1, p=0.009). The DD genotype of the ACE gene was associated with a significantly higher frequency of premature parental myocardial infarction compared to the II genotype (14% vs 6.1%; OR 3.1, p=0.009).
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