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January 1, 1995Japanese Heart JournalOpen Access

Association of ACE Gene Polymorphisms with Coronary Artery Disease in a Northern Area of Japan.

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Why the study?

Is the ACE gene insertion/deletion polymorphism associated with coronary artery disease in a northern Japanese population?

Population

202 subjects living in a northern part of Japan, comprising 109 patients with coronary artery disease and 93…

Comparison

Presence of the D-allele or DD genotype of the… vs Non-coronary subjects or other ACE genotypes

Design

Case-control

Authors

KTKentaro TakahashiAlnylam Pharmaceuticals (United States)HNHidenori NakamuraChiba-Nishi General HospitalIKIsao KubotaElectrophysiology

Discussion

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Implication

Supports CAD risk stratification by ACE genotype in normotensives; leaves open prospective confirmation in Japanese cohorts.

Structured PICO

Is the ACE gene insertion/deletion polymorphism associated with coronary artery disease in a northern Japanese population?

P
Population
202 subjects living in a northern part of Japan, comprising 109 patients with coronary artery disease (CAD) and 93 non-coronary subjects (NCS).
I
Intervention
Presence of the D-allele or DD genotype of the ACE gene insertion/deletion polymorphism
C
Comparator
Non-coronary subjects or other ACE genotypes (II, ID)
O
Outcome
Association with coronary artery disease (myocardial infarction and angina pectoris)hard clinical

The ACE gene DD genotype is associated with an increased risk of coronary artery disease in a northern Japanese population, particularly among normotensive individuals.

Cite This Study

Takahashi et al. (1995) studied this question.

synapsesocial.com/papers/6a8832f24c82be800eeb4e39https://doi.org/10.1536/ihj.36.557

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese.1994 · 275 citations
  2. 2A Prospective Evaluation of an Angiotensin-Converting–Enzyme Gene Polymorphism and the Risk of Ischemic Heart Disease1995 · 910 citations
  3. 3Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction1992 · 5,954 citations
  4. 4PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)1992 · 1,249 citations
  5. 5The effect of bronchitis, smoking, and occupation on ventilation.1963 · 296 citations