Why the study?
Is the ACE gene deletion/insertion polymorphism associated with an increased risk of ischaemic stroke?
Population
585 unselected suspected stroke patients admitted to the Acute Stroke Unit, Western Infirmary, Glasgow, and…
Comparison
Angiotensin converting enzyme gene… vs Age- and sex-matched controls without stroke
Design
Case-control
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ACE polymorphism should not guide stroke prevention; leaves open a potential DD effect confined to hypertensives.
Is the ACE gene deletion/insertion polymorphism associated with an increased risk of ischaemic stroke?
The ACE gene DD genotype does not appear to be a general risk factor for ischemic stroke, though it may confer increased risk specifically in hypertensive patients.
A 1995 study studied this question.
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