Why the study?
Does the ACE gene insertion/deletion polymorphism increase the risk of ischaemic stroke?
Population
200 individuals: 100 patients with cerebral infarction and 100 age- and sex-matched controls
Comparison
Presence of ACE gene insertion/deletion… vs Other ACE genotypes
Design
Case-control
Authors
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No association seen between ACE polymorphism and ischaemic stroke; leaves open its role in larger or diverse cohorts.
Does the ACE gene insertion/deletion polymorphism increase the risk of ischaemic stroke?
The ACE gene insertion/deletion polymorphism (specifically the DD genotype) does not appear to be a significant risk factor for ischaemic stroke.
Karagiannis et al. (2004) studied this question.