Why the study?
Does the ACE insertion/deletion polymorphism or plasma ACE activity affect the risk of stroke or early mortality in stroke patients?
Population
467 cases of stroke (pathological type established by cranial CT) and 231 control subjects
Comparison
Angiotensin-converting enzyme insertion/deletion… vs Control subjects without stroke, and comparison…
Design
Case-control
Follow-up
3 months
Authors
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Low plasma ACE activity and D allele count were associated with early stroke mortality; hypothesis-generating for ACE pathway studies and requires prospective validation.
Does the ACE insertion/deletion polymorphism or plasma ACE activity affect the risk of stroke or early mortality in stroke patients?
Low ACE activity at stroke presentation and possession of the D allele may be associated with an increased risk of early death from acute cerebral infarction.
Catto et al. (1996) studied this question.
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